Semiempirical (AM1, PM3 and SAM1) calculations of the protonation enthalpies of proton sponges related to 1,8-diaminonaphthalene. Estimation of the aqueous basicity of new designed superbases
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 5,p. 923-927
- https://doi.org/10.1039/p29950000923
Abstract
AM1, PM3 and SAM1 calculations have been carried out on eight compounds related to 1,8-diaminonaphthalene, five known proton sponges and three new compounds (a quinolizine, an isoquinoline and a 2,7-naphthyridine). The acceptable results obtained for the correlation between pKa and protonation enthalpies for the first five compounds using either the AM1 or the SAM1 method, gives confidence to the predicted high basicity (between 19 and 22 pKa units) for the unknown compounds.Keywords
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