Phencyclidine Abuse: Clinical Findings and Concentrations in Biological Fluids after Nonfatal Intoxication

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Abstract
Phencyclidine concentrations were measured in the plasmas of 22 patients with nonfatal phencyclidine intoxication using gas–liquid chromatography with a nitrogen detector. Concentrations found ranged from < 10 to 812 μg/l, and, except for the systolic blood pressure (r = 0.60, P < 0.05), showed no significant correlation with the physical findings. The most common physical findings were combativeness–agitation (64%), depressed level of consciousness (50%), hypertension (43%), miosis (43%), and tachycardia (43%). Phencyclidine concentrations measured in the erythrocytes of seven of the patients were generally higher than concentrations in the corresponding plasmas (erythrocyte:plasma concentration ratios ranged from 3.1 to 37.9), suggesting that the binding of phencyclidine to plasma proteins is low. Erythrocytic concentrations also showed no significant correlation with either the physical findings or the plasma concentrations of phencyclidine. For 15 unselected urines the concentrations of phencyclidine showed no significant correlation with urinary pH.

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