The angry back syndrome: eczema creates eczema

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Abstract
False positive patch test reactions are common when the skin of the back is hyper-reactive, Such reactions can obscure or invalidate observations of multiple specific sensitivity and of cross-sensitivity to contactants. The pathogenesis of the hyper-reactive skin (‘angry back’) is discussed and a mechanism postulated for the notion that eczema at certain sites can provoke an eczematous tendency at other sites.

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