STUDIES ON THE ACTION-PATTERN OF ANTITUBERCULAR SUBSTANCES
- 1 November 1954
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 41 (6) , 717-724
- https://doi.org/10.1093/oxfordjournals.jbchem.a126490
Abstract
When a cell suspension of M. tuberculosis avium is incubated with malonic acid, CO2-evolution occurs before O2-uptake, both after short lag periods. At equilibrium stage, both malonic and acetic acids give 1.5 mols. O2-uptake/mol. substrate, while CO2 evolution is 2.5 and 1.5 mols./mol. of malonic and acetic acids, respectively. These results may indicate the decarboxylative conversion of malonic acid into acetic acid. Enzymes responsible for malonic acid decarboxylation as well as for benzoic acid oxidation to catechol are presumably adaptively formed in a streptomycin-sensitive strain, especially under anaerobic conditions. The adaptation is suppressed by streptomycin, except with streptomycin-resistant strains.This publication has 0 references indexed in Scilit: