RENAL EXTRACTION OF PARA-AMINOHIPPURATE IN INFANTS AND CHILDREN*

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Abstract
Renal vein catheterization was performed in eight infants 8 days to 3 months old and in seven older infants and children between 5 months and ten years old to determine the renal extraction ratios of para-aminohippurate )PAH) and inulin. In four infants 3 months old or younger, with PAH in normal saline diluent there was a reduction in EPAH about 30% below the average adult value. The older children have values comparable to the adult average of 93.5. This decreased EPAH in infants under 3 months old is presumably due to a decrease in either total tubular mass or tubular cell function. When PAH is administered in 5% dextrose in water and the mixing time interval is less than 70 minutes, there is no difference between EPAH so obtained and those when normal saline is the diluent. Whenever glucose is a diluent and at various intervals, EPAH are lower for infants under 3 months old than for the older children.