Studies on Erythropoiesis. Part IV. Reticulocyte Response of Hypophysectomized and Polycythemic Rodents to Erythropoietin

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Abstract
Within 3-4 weeks after rats are hypophysectomized the number of their reticulocytes reaches a minimal level. This reduction is a 5-to 10-fold decrease as compared with the preoperative control. The decline is more rapid in 8-week-old rats than in younger animals. Administration of anemic plasma to hypophysectomized rats brings about an increase in the number of reticulocytes that is many times greater than that produced by normal plasma or saline. Erythropoiesis, measured by the number of reticulocytes in the peripheral blood, falls to 0 in 6 days in mice made polycythemic by repeated intraperitoneal injections of homologous red cells. Anemic plasma obtained from rats or rabbits produces a reticulocytosis that is many times greater than that observed from normal plasma when it is injected intravenously or intraperitoneally into polycythemic mice. In polycythemic mice and hypophysectomized rats, reticulocyte determinations in the peripheral blood and Fe59 red cell incorporation studies are of about equal sensitivity in measuring the response of these rodents to anemic plasma.

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