Cyanoacrylate Tissue Adhesive in Surgery in Anticoagulated Subjects

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Abstract
SURGERY upon patients who have clotting deficiencies or are receiving anticoagulants is a difficult problem. These situations, although not too common, are important from the surgical standpoint. When the patient is known to have clotting deficiency or has been anticoagulated, careful preparations to promote the clotting and all available precautions should be undertaken in elective surgery. However, in an emergency situation in which the clotting deficiency cannot be altered in a short period, surgery may add further complications and even cause death in the postoperative period because of hemorrhage. On some occasions it is desirable to continue the anticoagulation treatment during and after surgery. Since cyanoacrylate tissue adhesives polymerize in the presence of moisture on the wound,1this factor may be used advantageously in the above situations. The methyl cyanoacrylate monomer has been successfully used for hemostasis in suture line hemorrhage of sutured Teflon patch on the canine aorta.

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