Interaction of L-alpha-didecanoyl phosphatidylcholine with the AI polypeptide of high density lipoprotein.
Open Access
- 1 September 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (9) , 3796-3799
- https://doi.org/10.1073/pnas.74.9.3796
Abstract
Cooperative interaction of L-.alpha.-didecanoyl phosphatidylcholine with the AI polypeptide from human serum high density lipoprotein results in a complex particle containing 2 molecules of AI and 190 molecules of the lipid. Binding occurs 2 orders of magnitude above the critical micelle concentration of the lipid and requires the simultaneous presence of low levels of single-chain amphiphiles. The present investigation and previous studies from this laboratory suggest that AI contains pockets capable of interacting with a fixed hydrophobic volume and that amphiphilic head groups do not affect the binding capacity.This publication has 18 references indexed in Scilit:
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