Population imaging of ongoing neuronal activity in the visual cortex of awake rats
Top Cited Papers
- 15 June 2008
- journal article
- Published by Springer Nature in Nature Neuroscience
- Vol. 11 (7) , 749-751
- https://doi.org/10.1038/nn.2140
Abstract
It is unclear how the complex spatiotemporal organization of ongoing cortical neuronal activity recorded in anesthetized animals relates to the awake animal. We therefore used two-photon population calcium imaging in awake and subsequently anesthetized rats to follow action potential firing in populations of neurons across brain states, and examined how single neurons contributed to population activity. Firing rates and spike bursting in awake rats were higher, and pair-wise correlations were lower, compared with anesthetized rats. Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation. Overall, brain activity during wakefulness cannot be inferred using anesthesia.Keywords
This publication has 15 references indexed in Scilit:
- Spatial Organization of Neuronal Population Responses in Layer 2/3 of Rat Barrel CortexJournal of Neuroscience, 2007
- Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile MiceNeuron, 2007
- Correlation between neural spike trains increases with firing rateNature, 2007
- The Structure of Multi-Neuron Firing Patterns in Primate RetinaJournal of Neuroscience, 2006
- Whole-Cell Recordings in Freely Moving RatsNeuron, 2006
- Weak pairwise correlations imply strongly correlated network states in a neural populationNature, 2006
- Imaging input and output of neocortical networks in vivoProceedings of the National Academy of Sciences, 2005
- How Close Are We to Understanding V1?Neural Computation, 2005
- Pattern recognition computation using action potential timing for stimulus representationNature, 1995
- Two-Photon Laser Scanning Fluorescence MicroscopyScience, 1990