THE LEVELS OF FREE ASPARTIC ACID, GLYCINE, AND SERINE IN TISSUES OF BONE MARROW CHIMERAS

Abstract
Aspartic acid concentration is increased in livers of foreign bone marrow treated, irradiated mice. The serine and glycine concentration of liver, plasma, and muscle is decreased in these animals. The rate at which aspartic acid is labeled by carbon-14 injected as carbon-14 glucose is different in foreign marrow chimeras as compared to isologous marrow treated irradiated mice. This suggests that the increase in aspartic acid of liver is due to a fundamental alteration in metabolism of this amino acid in foreign marrow chimeras.

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