Involvement of Tumour Necrosis Factor and Other Cytokines in Immune-Mediated Vascular Pathology

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Abstract
Vascular endothelial cells are actively involved in coagulation and inflammation processes and appear to represent a important element in cell-mediated immune responses. In this paper, the possible role of endothelial cells as a target for immunopathological reactions was analyzed. Experimental neurovascular lesions were studied in a model of cerebral malaria, with particular attention to the role of cytokine interactions in vivo.