Cerebrospinal fluid penicillin levels during therapy for latent syphilis

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Abstract
CSF and serum penicillin levels were determined in patients with latent syphilis. Mean serum concentration 1 wk after the third weekly dose of 2.4 million units penicillin G benzathine was 0.32 U/ml. Concurrent administration of probenecid orally produced a mean serum penicillin level of 0.41 units/ml. Doubled penicillin doses without and with daily orally administered probenecid resulted in mean serum concentrations of 0.75 and 1.00 units/ml, respectively. Two of 6 patients in the last group had CSF penicillin concentrations greater than 0.03 units/ml.