HIGH-DOSE METHOTREXATE AND LEUCOVORIN RESCUE IN DOGS WITH OSTEOGENIC-SARCOMA

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (12) , 1943-1945
Abstract
Dogs (5) with osteogenic sarcoma were treated by surgical removal of the primary tumor and by adjuvant chemotherapy. Methotrexate at dosages of 3-6 g/m2 was used with leucovorin rescue. All dogs tolerated 3 g of methotrexate/m2 of body surface, but granulocytopenia precluded escalation beyond this dosage in 4 dogs. The rate and time of appearance of pulmonary metastases were not altered by treatment, with all dogs developing metastases at a median time of 4 mo. after amputation.