Oesophageal function before, during, and after healing of erosive oesophagitis.
Open Access
- 1 February 1988
- Vol. 29 (2) , 157-160
- https://doi.org/10.1136/gut.29.2.157
Abstract
In order to investigate the relationship between oesophageal motor abnormalities and oesophagitis, we carried out four hour studies of oesophageal motility and 24 hour pH measurements in fasting and fed conditions in eight patients before, during (pH only), and after medical healing of erosive oesophagitis. Gastrooesophageal acid reflux decreased (ns) during the treatment, but tended to return to basal values at the end. Oesophageal body motility was unchanged after healing, while the lower oesophageal sphincter basal tone was significantly increased at the end of the study in the postcibal period. The results suggest that the impairment of the sphincter tone in reflux oesophagitis is secondary to the presence of the oesophageal lesions. Macroscopic healing is not paralleled by improved major pathogenic factors of the disease, however--that is, acid reflux and oesophageal body motility.This publication has 17 references indexed in Scilit:
- Oesophageal motor events at the occurrence of acid reflux and during endogenous acid exposure in healthy subjects and in patients with oesophagitis.Gut, 1985
- When is esophagitis healed?Digestive Diseases and Sciences, 1982
- Does Surgery Correct Esophageal Motor Dysfunction in Gastroesophageal Reflux?Annals of Surgery, 1981
- Effect of long-term treatment with cimetidine and antacids in Barrett's oesophagus.Gut, 1981
- Oral cimetidine in reflux esophagitis: A double blind controlled trialGastroenterology, 1978
- Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial.1978
- Studies on the Mechanism of Esophagitis-Induced Lower Esophageal Sphincter Hypotension in CatsGastroenterology, 1976
- Experimental Esophagitis in Cats Impairs Lower Esophageal Sphincter PressureGastroenterology, 1975
- Effect of dry swallows and wet swallows of different volumes on esophageal peristalsisJournal of Applied Physiology, 1975
- A comparison between primary esophageal peristalsis following wet and dry swallows.Journal of Applied Physiology, 1973