Anti-Chromium Barrier Creams

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Abstract
Disappearance measurements have been used for studying the inhibiting effect of barrier creams on chromate (51Cr) absorption in the guinea pig. The creams Bakosan, Dow (Silicones), Indulona, Ivosin, Kerodex 71 and petrolatum were applied in different volumes (0.05–0.15 ml/cm2) and the interval between application of cream and chromate was varied. Ivosin (ion exchanger) was the most effective absorption-inhibiting preparation. Only at 0.15 ml/cm2 was Dow equally effective. The protective effect of Bakosan, Indulona, Kercdex and petrolatum diminished when the volume was raised to 0.15 ml/cm3. Increasing the interval resulted in no change (Ivosin), a decrease (Bakosan, Indulona), and an increase in absorption for the other creams. Film thickness and interval before exposure have clinical implications.

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