Interhemispheric Fissure Sign of Dysgenesis of the Corpus Callosum

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Abstract
Failure to develop of the corpus callosum and the neighboring midline structures results in abnormal proximity between the interhemispheric fissure (IHF) and the 3rd ventricle. This finding was named the IHF sign of dysgenesis of the corpus callosum (DCC). In a retrospective study of 39 [human] cases the presence of the IHF sign was assessed in conjunction with the other well recognized CT [computed tomography] manifestations of the disorder. These are: lateral ventricles: pointing of the frontal horns, disproportionate enlargement of the occipital horns and separation of bodies of the lateral ventricles; 3rd ventricle; enlargement, elevation and anterior displacement; and interventricular foramen: enlargement. The IHF sign apparently was present concurrently with the other CT signs of DCC in all 35 cases (100%) where the quality of the CT scans permitted its satisfactory evaluation; in the remaining 4 the sign could not be assessed because of the unsatisfactory quality of the CT scans. The IHF sign evidently is an additional reliable CT feature of DCC.

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