Regulation of high affinity choline uptake
- 1 March 1990
- journal article
- research article
- Published by Wiley in Journal of Neurobiology
- Vol. 21 (2) , 269-275
- https://doi.org/10.1002/neu.480210202
Abstract
High affinity uptake of choline, the rate‐limiting, regulatory step for the synthesis of acetylcholine (ACh), was found to be regulated via presynaptic auto‐ and hetero‐receptors. The transport rate was reduced by a muscarinic agonist and neuropeptides, but was significantly enhanced by octopamine. Intracellular messengers, including cyclic nucleotides, appear to modulate the transport activity, apparently by activating specific protein kinases.This publication has 22 references indexed in Scilit:
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