Ventricular tachycardia-flutter associated with disopyramide therapy: a report of three cases.

  • 1 September 1978
    • journal article
    • case report
    • Vol. 7  (5) , 783-7
Abstract
Three patients developed episodes of ventricular tachycardia and/or flutter-fibrillation while receiving disopyramide (Norpace). Syncope was the presenting complaint in all of them. The arrhythmias did not recur after disopyramide was discontinued. The Q-T interval was markedly prolonged in all three patients. One patient developed syncope associated with both quinidine and Norpace therapy. It is postulated that disopyramide, like quinidine, may provoke ventricular flutter-fibrillation in sensitive patients by similar mechanisms.

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