RED-CELL URIDINE MONOPHOSPHATE KINASE - EFFECTS OF RED-CELL AGING ON ACTIVITY OF 2 UMPK GENE PRODUCTS
- 1 January 1976
- journal article
- research article
- Vol. 28 (2) , 138-142
Abstract
Uridine monophosphate kinase (UMPK) was previously reported to be genetically polymorphic in man. The UMPK2 gene product has less activity than that of UMPK1 when measured in normal red cells. The activity of UMPK, like that of many other enzymes, declines during red cell aging, and the lower activity of UMPK 2, as compared with UMPK 1, is best explained by its more rapid catabolism.This publication has 6 references indexed in Scilit:
- Uridine monophosphate kinase: A new genetic polymorphism with possible clinical implications.1974
- Influence of temperature and method of centrifugation on the separation of erythrocytes.1973
- Phosphoglycerate kinase: an X-linked polymorphism in man.1971
- Enzymes of Nucleic Acid MetabolismAnnual Review of Biochemistry, 1970
- In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and Gdmediterranean deficiencyJournal of Clinical Investigation, 1968
- ENZYMES AS ERYTHROCYTE AGE REFERENCE STANDARDSThe Lancet Healthy Longevity, 1967