Effect of Alloxan Diabetes on Phosphatidylcholine Biosynthetic Enzymes

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Abstract
Phosphatidylethanolamine methyltransferase, phosphatidyldimethylethanolamine methyltransferase and choline phosphotransferase enzymatic activities (nmol phosphatidylcholine formed/min per mg protein) were determined in liver microsomes of alloxan diabetic rats. There was a significant reduction in the methylation pathway in the conversion of phosphatidylethanolamine to PC as demonstrated in the low value of the phosphatidylethanolamine methyltransferase and phosphatidyldimethylethanolamine methyltransferase in those diabetic rats with blood glucose levels greater than 600 mg%. The reduction was 49 and 48% decrease over controls, respectively. There was a significant increase in the choline phosphotransferase in the diabetic rats. The increase was 92% over controls for the rats with blood glucose of 461 mg% and 55% over controls for the rats with blood glucose 946 mg%.