Systemic Administration of Immunostimulatory DNA Sequences Mediates Reversible Inhibition of Th2 Responses in a Mouse Model of Asthma
- 1 January 2001
- journal article
- Published by Springer Nature in Journal of Clinical Immunology
- Vol. 21 (3) , 175-182
- https://doi.org/10.1023/a:1011078930363
Abstract
This study investigated whether immunostimulatory DNA sequences (ISS) induce a transient or sustained inhibition of Th2 responses to inhaled antigen. We sensitized mice with subcutaneous injections...Keywords
This publication has 20 references indexed in Scilit:
- Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitisEuropean Journal of Immunology, 2000
- Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicityJournal of Allergy and Clinical Immunology, 2000
- Could Asthma Be Worsened by Stimulating the T-helper Type 1 Immune Response?American Journal of Respiratory Cell and Molecular Biology, 2000
- Could the Risk of Asthma and Atopy Be Reduced by a Vaccine That Induces a Strong T-helper Type 1 Response?American Journal of Respiratory Cell and Molecular Biology, 2000
- CpG‐oligodeoxynucleotides enhance T‐cell receptor‐triggered interferon‐γ production and up‐regulation of CD69 via induction of antigen‐presenting cell‐derived interferon type I and interleukin‐12Immunology, 2000
- CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthmaJournal of Allergy and Clinical Immunology, 1999
- Oligodeoxynucleotides containing CpG motifs modulate the allergic T H2 response of BALB/c mice to Bet v 1, the major birch pollen allergenJournal of Allergy and Clinical Immunology, 1999
- Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammationJournal of Clinical Investigation, 1999
- DNA–Based Immunization for AsthmaInternational Archives of Allergy and Immunology, 1999
- Inhibition of IgE formation and allergic inflammation by allergen gene immunizationAllergy, 1998