EFFECT OF BUTHUS-EUPEUS TOXINS ON SODIUM-CHANNELS OF RANVIER NODE MEMBRANE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 24  (2) , 235-241
Abstract
Effect of 3 toxins M3, M7 and M8 from B. eupeus poison on the Na channels of Ranvier node membrane of the frog was studied with potential fixation. Toxin M3 produced no effect on Na currents of Ranvier node membrane of the frog. Inactivation kinetics difference between normal and modified Na channels was used in estimating a fraction of toxin-modified channels. The toxins interacted with the channels in the ratio 1:1, the dissociation constants for M7 and M8 equaling 1.7 .times. 10-7 M and 0.9 .times. 10-9 M, respectively. Dependence of the effect of scorpion toxins on the membrane potential is stated.