The influence of compression and formulation on the hardness, disintegration, dissolution, absorption and excretion of sulphadimidine tablets

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Abstract
Sulphadimidine tablets were prepared with different binding agents and compressed at different compression levels, ranging from 200–2000 MNm2. The disintegration time and dissolution rate of the different tablets were determined. Tablets formulated with gelatin or starch mucilage and compressed at 600 MNm2 were selected for in vivo experiments using a urinary excretion method. Although both tablets complied with the disintegration requirements of the British Pharmacopoeia, dissolution rate and urinary excretion showed a difference in availability of drug from the two tablets.

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