Rat intestinal epithelial cell line IEC‐6 is activated by recombinant inferferon‐γ to inhibit replication of the coccidian Toxoplasma gondii
- 1 April 1993
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 23 (4) , 981-983
- https://doi.org/10.1002/eji.1830230435
Abstract
Toxoplasma gondii tachyzoites invaded and replicated in cultured rat small intestine cells of the line IEC-6. Treatment of rat small intestine cells with murine recombinant interferon-y resulted in a dose-dependent inhibition of intracellular T. gondii replication. This could be of relevance as a first line defense against Toxoplasma infection.Keywords
This publication has 11 references indexed in Scilit:
- Human endothelial cells are activated by IFN-gamma to inhibit Toxoplasma gondii replication. Inhibition is due to a different mechanism from that existing in mouse macrophages and human fibroblasts.The Journal of Immunology, 1991
- Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.The Journal of Immunology, 1990
- MHC class II expression by the gut epitheliumImmunology Today, 1988
- Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondiiScience, 1988
- In vitro and in vivo activation of human mononuclear phagocytes by interferon-gamma. Studies with normal and AIDS monocytes.The Journal of Immunology, 1987
- How Does Toxoplasma gondii Enter Host Cells?Clinical Infectious Diseases, 1985
- Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.Proceedings of the National Academy of Sciences, 1984
- Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates.The Journal of Experimental Medicine, 1979
- Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria.The Journal of cell biology, 1979