Acremonium strictum Pulmonary Infection in a Leukemic Patient Successfully Treated with Posaconazole After Failure of Amphotericin B
- 1 November 2002
- journal article
- case report
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 21 (11) , 814-817
- https://doi.org/10.1007/s10096-002-0828-8
Abstract
A severely neutropenic patient with chronic lymphocytic leukemia developed a diffuse bilateral pulmonary infection while receiving a therapeutic daily dosage of intravenous amphotericin B for Candida glabrata esophagitis. Computed tomography of the chest showed numerous lung nodules, ground glass areas and a pleural effusion. Biopsy of one nodule demonstrated hyaline septate hyphae. Multiple sputum cultures grew Acremonium strictum. Increasing the dose of amphotericin B and the addition of itraconazole did not resolve the infection. Change of treatment to posaconazole given orally at 200 mg four times/d resulted in progressive improvement leading finally to cure after 24 weeks of therapy. Treatment with posaconazole was clinically and biologically well tolerated.Keywords
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