Use of palladium(II) chloride as a colour-forming reagent for the determination of N-acetyl-L-cysteine in water and Fluimukan injections

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Abstract
The formation of the complex between N-acetyl-L-cysteine and palladium(II) chloride in Britton-Robinson buffer solution in the pH range 2.08–8.00 was studied. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of N-acetyl-L-cysteine in the concentration range 4.0–65.3 µg ml–1, using PdCl2 as the reagent. The detection limit was 1.63 µg ml–1 and the relative standard deviation varied from 0.63 to 1.92%. The method was applied to the determination of N-acetyl-L-cysteine in water and in injection solutions.