Lineage relationship and protective immunity of memory CD8 T cell subsets
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- 3 February 2003
- journal article
- Published by Springer Nature in Nature Immunology
- Vol. 4 (3) , 225-234
- https://doi.org/10.1038/ni889
Abstract
Memory CD8 T cells can be divided into two subsets, central (T(CM)) and effector (T(EM)), but their lineage relationships and their ability to persist and confer protective immunity are not well understood. Our results show that T(CM) have a greater capacity than T(EM) to persist in vivo and are more efficient in mediating protective immunity because of their increased proliferative potential. We also demonstrate that, following antigen clearance, T(EM) convert to T(CM) and that the duration of this differentiation is programmed within the first week after immunization. We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway.Keywords
This publication has 56 references indexed in Scilit:
- Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ CellsThe Journal of Experimental Medicine, 2002
- Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T CellsThe Journal of Experimental Medicine, 2002
- Effector and memory T-cell differentiation: implications for vaccine developmentNature Reviews Immunology, 2002
- Migratory Properties of Naive, Effector, and Memory Cd8+ T CellsThe Journal of Experimental Medicine, 2001
- Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virusEuropean Journal of Immunology, 2001
- Control of Homeostasis of CD8 + Memory T Cells by Opposing CytokinesScience, 2000
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999
- Linear Differentiation of Cytotoxic Effectors into Memory T LymphocytesScience, 1999
- Phenotypic and Functional Separation of Memory and Effector Human CD8+ T CellsThe Journal of Experimental Medicine, 1997
- Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient miceImmunity, 1994