A simple construction of the hydroxy-ketone side chain of corticosteroids from 17-oxo-steroids via nitro-olefins
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 551-552
- https://doi.org/10.1039/c39820000551
Abstract
17-Oxo-steriods, in the presence of catalytic amounts of ethylenediamine, react smoothly with nitromethane to give the corresponding nitro-olefins; these are easily transformed into 21-hydroxy-20-oxo-corticosteroids with or without a double bond at position 16.Keywords
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