TRIFLUOPERAZINE ANTAGONIZES INHIBITION OF RENIN RELEASE BY ANGIOTENSIN II
- 1 October 1983
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 10 (5) , 605-608
- https://doi.org/10.1111/j.1440-1681.1983.tb00229.x
Abstract
The influence of trifluoperazine (TFP) treatment on angiotensin II-induced inhibition of renin release from the rat isolated perfused kidney was examined. Angiotensin II, 1 mumol/l, in the presence of 1 mmol/l calcium, reduced basal renin secretion by 70%. When calcium was omitted from the perfusion medium, inhibition of renin release no longer occurred. Pretreatment of the rat isolated perfused kidney with the calmodulin inhibitor trifluoperazine (TFP), 10 mumol/l for 6 min, interfered with the inhibitory action of angiotensin II on renin release as well as angiotensin II-induced renal vasoconstriction. Our data suggest a role for calmodulin in mediating the effects of angiotensin II on both renin release and renal vascular resistance.Keywords
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