Comparative analysis of biological activities of Der p I-derived peptides on Fc receptor-bearing cells from Dermatophagoides pteronyssinus-sensitive patients
- 1 April 1993
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 92 (1) , 133-138
- https://doi.org/10.1111/j.1365-2249.1993.tb05959.x
Abstract
SUMMARY: The ability of Tour uncoupled synthetic peptides (p52–71, p117–133, p176–187, p188–199) derived from Der p I, a major allergen from the house dust mite Dermatophagoides pteronyssinus (Dpt) to stimulate FcεR+ cells from Dpt-sensitive patients was comparatively analysed. Each free peptide may specifically stimulate basophils (FcεRI+ cells) and platelets (FcεRII+ cells) from patients with significant levels of anti-Der p I IgE antibodies; p52–71 and p 117–133 appear the best cell stimulation inducers. Both concentration-dependent biological activities of Der p I-peptide on FcεR+ cells are enhanced by coupling peptide to a carrier (as human serum albumin). Interestingly each Der p I sensitive patient tested presents an individual pattern of response to peptide. Thus, from our results it appears that different Der p I sequences could be involved in the immune response to Der p I.Keywords
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