Association of a Polymorphism in the TNFR2 Gene with Low Bone Mineral Density
- 1 July 2000
- journal article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 15 (7) , 1376-1383
- https://doi.org/10.1359/jbmr.2000.15.7.1376
Abstract
Previous genetic linkage data suggested that a gene on chromosome 1p36.2–36.3 might be linked to low bone mineral density (BMD). Here, we examine the gene for tumor necrosis factor receptor 2 (TNFR2), a candidate gene within that interval, for association with low BMD in a group of 159 unrelated individuals. We assess two polymorphic sites within the gene, a microsatellite repeat within intron 4, and a three-nucleotide variation in the 3′ untranslated region (UTR) of the gene. The latter has five alleles of which the rarest allele is associated with low spinal BMD Z score (p = 0.008). Lowest mean spinal BMD Z scores were observed for individuals having genotypes that were heterozygous for the rarest allele. No homozygotes for the rarest allele were observed. Preliminary analysis suggests that there is a difference in the genotype frequency distribution between the group with low BMD and a control group.Keywords
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