Some considerations on quantitative methodology and detection limits in organic mass spectrometry

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Abstract
Mass spectrometric sensitivity data for the compounds cholesterol, cholestane, DDT, decafluorotriphenyl-phosphine, morphine, LSD and methyl stearate have been developed over a period of time and under a variety of conditions. This information is presented on both a relative and an absolute basis. With the exception of morphine, relative sensitivities were repoducible to within a factor of three over a six month period. This reproducibility facilitates quantitation and a single standard can be used for calibration of organic compounds from various classes. Detection limits of 50 femtograms for LSD are realized for samples introduced via the direct inlet probe.