Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp.1
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 61 (19) , 6594-6600
- https://doi.org/10.1021/jo960877+
Abstract
In addition to the previously reported bioactive kahalalide F six new peptides are described. Six of these, including kahalalide F, are cyclic depsipeptides, ranging from a C31 tripeptide to a C75 tridecapeptide isolated from a sacoglossan mollusk, Elysia rufescens. The mollusk feeds on a green alga, Bryopsis sp., which has also been shown to elaborate some of these peptides in smaller yields, in addition to an acyclic analog of F, kahalalide G. The bioassay results of antitumor, antiviral, antimalarial, and OI (activity against AIDS opportunistic infections) tests are reported.Keywords
This publication has 9 references indexed in Scilit:
- Structure of cypemycin, a new peptide antibioticTetrahedron Letters, 1994
- Kahalalide F: a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis spJournal of the American Chemical Society, 1993
- High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoidsJournal of the American Chemical Society, 1991
- Chemical Ecology of the NudibranchsPublished by Springer Nature ,1987
- Metal vapor synthesis of a novel triple-decker sandwich complex: (.eta.6-mesitylene)2(.mu.-.eta.6:.eta.6-mesitylene)Cr2Journal of the American Chemical Society, 1986
- Free radicals in lipid bilayers: new probes of lipid radical dynamicsJournal of the American Chemical Society, 1984
- Separation of the optical isomers of amino acids by ligand-exchange chromatography using chemically bonded chiral phasesJournal of Chromatography A, 1981
- The Varied and Fascinating Chemistry of Marine MollusksIsrael Journal of Chemistry, 1977
- SYMBIOTIC CHLOROPLASTS; THEIR PHOTOSYNTHETIC PRODUCTS AND CONTRIBUTION TO MUCUS SYNTHESIS IN TWO MARINE SLUGSThe Biological Bulletin, 1972