Insulin-Sepharose and the Dynamics of Insulin Action
Open Access
- 1 September 1971
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (9) , 2066-2068
- https://doi.org/10.1073/pnas.68.9.2066
Abstract
In terms of the rate of accumulation of α-aminoisobutyric acid, mammary epithelial cells from mature virgin mice respond rapidly to insulin covalently bound to sepharose particles, but do not respond initially to soluble insulin in vitro. The response to insulin-sepharose is prevented if the cells are first exposed to insulin. These observations may provide new insight into the dynamics of insulin action.Keywords
This publication has 6 references indexed in Scilit:
- The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action.1971
- Development of Insulin-Sensitivity by Mouse Mammary Gland In VitroProceedings of the National Academy of Sciences, 1970
- INTERACTION OF INSULIN WITH THE CELL MEMBRANE: THE PRIMARY ACTION OF INSULINProceedings of the National Academy of Sciences, 1969
- A NOVEL ACTION OF INSULIN ON PHOSPHOPROTEIN FORMATION BY MAMMARY GLAND EXPLANTSProceedings of the National Academy of Sciences, 1969
- DIVISION OF BIOCHEMISTRY: MULTIPLE HORMONE INTERACTIONS RELATED TO THE GROWTH AND DIFFERENTIATION OF MAMMARY GLAND IN VITRO*Transactions of the New York Academy of Sciences, 1968