Effects of angiotensins on the motility of human sperm.

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Abstract
The effects of angiotensins on the motility of highly washed human sperm were examined by .apprx. multiple exposure photography system. The addition of low doses (0.1-10 ng/ml) of angiotensin II (AT II) stimulated the forward velocity of sperm without increasing the percentage of motility. A high concentration (1.0 .mu.g/ml) of AT II suppressed the motility. The direct effect of angiotensin I on the motility was observed under the presence of SQ 14225 [D-3-mercapto-2-methylpropanoyl-L-proline], a specific inhibitor of angiotensin I converting enzyme (ACE). AT I (0.1-100 ng/ml) had no influence on the motility, whereas a high dose (1.0 .mu.g/ml) suppressed the motility in the same manner as the corresponding dose of AT II. The action of AT II on the motility was completely suppressed under the coexistense of saralasin, a specific antagonist against AT II. The action of AT II on the sperm was evidently through the specific receptor on sperm.