Interactions among Epinephrine, Thyrotropin (TSH)-Releasing Hormone, Dopamine, and Somatostatin in the Control of TSH Secretionin Vitro
- 1 March 1984
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 114 (3) , 957-961
- https://doi.org/10.1210/endo-114-3-957
Abstract
Epinephrine and TRH independently release TSH from rat anterior pituitary cells in primary monolayer culture (ED50, 11 and 5 nM, respectively; maximum responses, 80 and 110%, respectively). The effects of these compounds together are additive, even at concentrations at which each is maximally effective alone. Dopamine inhibited basal and epinephrine-stimulated TSH secretion by 25 .+-. 5% (.+-. SE; ED50, 50 .+-. 9 nM in each case). Somatostatin was effective against epinephrine-stimulated, but not basal, TSH secretion (80 .+-. 4% inhibition; ED50 1 .+-. 3 nM). Epinephrine is a potential regulator of TSH secretion by its own action and via its interactions with TRH, dopamine and somatostatin.This publication has 3 references indexed in Scilit:
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