Hypoglycemic Action of Sulfanilamido-cyclopropylthiazole in Rabbits, and Its Reversal by Alloxan

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Abstract
2 -Sulfanilamido - 5-cyclopropyl -1,3,4 -thi -adizole, like other sulfonamides, has a chemotherapeutic action against certain pathogenic bacteria. It has a low toxicity. There is no evidence of conjugation as judged by blood examination. When given to normal rabbits, the substance uniformly causes hypoglycemia[long dash]with or without a slight initial rise of blood sugar. In diabetic rabbits (alloxan), it produces a definite rise of blood sugar.

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