The Crystal Structure of Riboflavin Hydrobromide Monohydrate

Abstract
The crystal structure of riboflavin hydrobromide monohydrate has been determined by a three-dimensional X-ray analysis. The space group is P 212121 with four formula units in the unit cell of dimensions a=18.28, b=6.99 and c=14.77 Å. The structural parameters were refined by means of a block-diagonal least-squares method, the final R factor being 0.07. The ribitol does not form a furanose ring but a chain. The protonation of the isoalloxazine ring occurs at the N(1) atom, and the C(4a)-N(10) bond is found to be a double bond. The bromide ion is situated midway between two isoalloxazine rings separated by a period along the b axis.

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