The role of neuropeptides in psoriasis
- 14 September 2006
- journal article
- review article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 155 (5) , 876-882
- https://doi.org/10.1111/j.1365-2133.2006.07518.x
Abstract
The pathogenesis of psoriasis is incompletely understood but cutaneous neurogenic inflammation is probably involved. This involvement is suggested by a number of clinical and histological observations. Reports about the distribution of cutaneous nerves and the quantification of nerve growth factor and neuropeptides, including calcitonin gene‐related peptide and vasoactive intestinal peptide, in lesional and nonlesional psoriatic skin suggest that sensory neuropeptides contribute to the development of psoriasis. This review summarizes what is known about the role of neurogenic markers in psoriasis.Keywords
This publication has 68 references indexed in Scilit:
- Atopic dermatitis, stinging, and effects of chronic stress: A pathocausal studyJournal of the American Academy of Dermatology, 2004
- Psoriatic Keratinocytes Express High Levels of Nerve Growth FactorActa Dermato-Venereologica, 1998
- Neuropeptides and general neuronal marker in psoriasis an immunohistochemical studyClinical and Experimental Dermatology, 1995
- Neuropeptides in skinJournal of the American Academy of Dermatology, 1995
- Peptide T improves psoriasis when infused into lesions in nanogram amountsJournal of the American Academy of Dermatology, 1991
- Substance P primes human neutrophil activation: A mechanism for neurological regulation of inflammationBiochemical and Biophysical Research Communications, 1989
- High-level expression of the simian virus 40 genes LP1, VP1 and VP2 as fusion proteins in Escherichia coliGene, 1988
- Stress, symmetry, and psoriasis: Possible role of neuropeptidesJournal of the American Academy of Dermatology, 1986
- The complete sequence of human preprocalcitoninFEBS Letters, 1984
- NEURAL MECHANISMS INVOLVED IN ITCH, “ITCHY SKIN,” AND TICKLE SENSATIONSJournal of Clinical Investigation, 1951