Development of Hymenolepis diminuta (Rudolphi, 1819) in Mice Made Obese by Aurothioglucose

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Abstract
Of 182 Swiss-strain mice injected intramuscularly with aurothioglucose 37 ultimately became obese. Development of obesity was followed for 100 days with records of food consumed, gains in weight, and fecal production. Eighty days after injections ten obese and ten control mice were multiply infected with pretreated cysticercoids of Hymenolepis diminuta. Ten days later hosts were sacrificed and tapeworms recovered. Lengths and weights were recorded and whole mounts prepared. Obese hosts consumed on the average 3 g more food per day, were 2.3 times heavier, and had small intestines one-third longer than control mice, and yielded, unexpectedly, worms significantly shorter and lighter in weight than those from normal mice. Moreover, worms from obese hosts had only 35 near-mature and mature proglottids; whereas, worms from controls had 117. Possible explanations of these inhibitions are discussed.

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