Use of DTPA for Increasing the Rate of Elimination of Plutonium-238 and Americium-241 from Rodents after their Inhalation as the Nitrates

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Abstract
This study has shown that: 1 both inhaled (2 μmol/kg) and injected (30 μmol/kg) diethylenetriaminepentaacetic acid (DTPA) can reduce the lung deposit of 238Pu and 241 Am inhaled as nitrate to about 1% of that in untreated controls; 2 injection of DTPA is more effective than aerosolized DTPA for reducing deposits of 238 Pu and 241Am in the liver and skelton; 3 combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.