SECRETIN-INDUCED INSULIN RESPONSE
- 1 June 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 82 (2) , 312-317
- https://doi.org/10.1530/acta.0.0820312
Abstract
Twenty-four patients (5 normals, 5 obese subjects, 9 normal wt maturity-onset diabetics and 5 obese maturity-onset diabetics) were subjected to stimulation with the gastro-intestinal hormone secretion (GIH, Stockholm, Sweden). Secretin was administered by rapid i.v. injection 6 times every 30 min in doses increasing from 0.9-90 pmol/kg body wt. Radioimmunological insulin assay and blood glucose determination were carried out. The secretin-induced maximum insulin response rose in all groups with increasing doses. D50 (16 pmol/kg body wt) was identical in all 4 groups. The diabetic .beta. cells exhibited the same sensitivity to secretion as the normals. Obese subjects already showed a significant insulin response after 0.9 pmol secretin/kg; the response of normal weight subjects did not rise until the dose was 36 pmol/kg. This, combined with the normal D50, indicates an increased .beta. cell mass in obese subjects.This publication has 1 reference indexed in Scilit: