A new chiral ferrocenylphosphine ligand with C 2 symmetry: prepration and use for palladium-catalysed asymmetric cross-coupling
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 8,p. 495-496
- https://doi.org/10.1039/c39890000495
Abstract
A new chiral ferrocenylphosphine ligand, which has C2-symmetric structure and a functional group on the side chain, was prepared by ortho-lithiation and phosphination of 1,1′-bis[1-(N,N-dimethylamino)ethyl]ferrocene followed by optical resolution of the ditartrate salts and was found to be effective for palladium-catalysed asymmetric cross-coupling of 1-phenylethylzinc chloride with vinyl bromide giving 3-phenylbut-1-ene of over 90% e.e.Keywords
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