The Potential Advantages and Requirements of Live Attenuated Influenza Virus Vaccines*
- 1 August 1977
- journal article
- review article
- Published by Wiley in Australian and New Zealand Journal of Medicine
- Vol. 7 (4) , 431-437
- https://doi.org/10.1111/j.1445-5994.1977.tb04412.x
Abstract
Live attenuated influenza A virus vaccines are potentially the most efficient and effective method of immunization against epidemic influenza, and offer the only feasible means of mass [human] vaccination at a socially acceptable cost. The advantages of live virus vaccines are described and compared with killed virus vaccines in terms of immune responses, protection and commercial production. The most frequently considered methods of attenuation and their individual drawbacks are discussed with speculation on the future development and rationale of master vaccine strains. Recommended minimal requirements of master vaccine strains and candidate live vaccines are presented as a basis for their eventual evaluation by licensing authorities.This publication has 37 references indexed in Scilit:
- Use of temperature-sensitive mutants of influenza A virus as live virus vaccine strains. Evaluation in laboratory animals, adults and childrenPostgraduate Medical Journal, 1976
- Protective efficacy of a live, attenuated, influenza virus vaccine (‘Alice’ strain)Published by Oxford University Press (OUP) ,1976
- Virulence of temperature-sensitive mutants of foot-and-mouth disease virusArchiv für die gesamte Virusforschung, 1975
- Immune Response of the Human Respiratory Tract. II. Cell-mediated Immunity in the Lower Respiratory Tract to Tuberculin and Mumps and Influenza VirusesThe Journal of Infectious Diseases, 1973
- Correlation between TS phenotype and pathogenicity of some animal virusesArchiv für die gesamte Virusforschung, 1973
- Prevalence of Antibody to Current Influenza Viruses and Effect of Vaccination on Antibody ResponseBMJ, 1972
- The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B virusesEpidemiology and Infection, 1972
- Temperature-Sensitive Mutants of Influenza Virus. II. Attenuation of ts Recombinants for ManThe Journal of Infectious Diseases, 1972
- Virulence of Temperature-sensitive Mutants of Influenza VirusBMJ, 1969
- Live influenza B vaccine in volunteersEpidemiology and Infection, 1969