INABILITY OF IMIPRAMINE TO PROTECT AGAINST TYPE-A OR TYPE-B MONO-AMINE OXIDASE INHIBITION BY PARGYLINE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (2) , 411-414
Abstract
Imipramine (30 mg/kg i.p.), a tricyclic antidepressant, did not antagonize the inhibition of type A or type B MAO [monoamine oxidase] by pargyline in brain, heart or liver of rats. Occupancy of active sites on mitochondrial MAO by imipramine probably does not occur at doses of imipramine adequate to inhibit monoamine uptake.

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