An Improved Synthesis of Azidothymidine
- 1 April 1996
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 15 (4) , 899-906
- https://doi.org/10.1080/07328319608002136
Abstract
A convenient and high yielding procedure is described for a direct conversion of thymidine (1) into 2,3′-anhydrothymidine (2) using the Mitsunobu reaction. Isolation and characterization of two new compounds, 3 and 4, are discussed. AZT has been synthesized from 1 in two steps, in 62% overall yield, by heating 2 with NaN3 in DMF.Keywords
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