Creatine Metabolism in Hyperthyroidism.

Publisher Website
Google Scholar
Abstract
Hyperthyroidism was induced in rats by thyroxine injections and by feeding of desiccated thyroid. Normal and hyperthyroid rats were injected with glycine-l-C14 and the incorporation of the isotope into glycocyamine and creatine was determined. In other experiments normal and hyperthyroid rats were injected with creatine-1-C14 and its incorporation into skeletal muscle and heart creatine was determined Hyperthyroidism increased creatinuria, increased heart weight and decreased heart creatine concentration. Hyperthyroidism led to an increased incorporation of glycine into liver creatine and to a decreased incorporation into skeletal muscle and heart creatine. It is concluded that the creatinuria of hyperthyroidism is the result of a block in the incorporation of creatine into skeletal muscle and cardiac muscle.

This publication has 2 references indexed in Scilit: