Congenital Deficiency of C2 and Factor B

Publisher Website
Google Scholar
Abstract
To the Editor: Recently, Newman et al.1 reported decreased levels of properdin factor B in three homozygous C2-deficient children, an association attributed to the linkage between genes coding for the two proteins. The authors cite the papers by Glass2 and Raum3 and their colleagues as in agreement. In the paper by Glass et al.2 the only person with homozygous C2 deficiency, a patient with systemic lupus erythematosus, had a factor B level of 320 μg per milliliter, which was within the normal range. This paper reported a statistical difference in factor B levels between heterozygous C2-deficient and normal family members . . .