Solute Equilibrium over the Extracellular Fluid Space in Haemorrhagic Hypotension: A Study in a Cannulated Thoracic Duct Model

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Abstract
Hemorrhagic hypotension, 50 mm Hg, was inflicted on non-starved rats. Osmolar and solute developments were followed in lymph and arterial plasma to assess diffusion and equilibration characteristics of the initial stages of hemorrhage. Lymph flow changes have reflected an intracellular fluid mobilization to the interstitium, caused by an osmotic gradient due to the elevated levels of glucose. A fluid homeostatic effect of pseudodiabetes associated with stress and hemorrhage is postulated.