Chemoradiotherapy for Localized Non-Hodgkin's Lymphoma

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Abstract
The search for the optimal treatment for localized intermediate- and high-grade non-Hodgkin's lymphoma has progressed through several phases in recent decades. In the 1960s and early 1970s, irradiation had a prominent, if not exclusive, role. However, radiation oncologists soon had to admit that the results achieved by irradiation alone were not satisfactory.1 In the early 1980s, a number of oncologists, carrying matters to the other extreme, advocated chemotherapy alone for localized lymphomas with unfavorable histologic features.2 Since then, the issue of how to treat localized intermediate- and high-grade non-Hodgkin's lymphoma has divided the world of lymphoma specialists into three parts. . . .